You’re using the wrong example. The aspirin comparison applies to the risk/benefit analysis. The meaningful comparison for lifelong use is insulin, as I also mention.
In addition, the question isn’t whether taking this drug forever is better than not taking this drug forever. The question is whether taking this drug forever is better than having common issues that many people with obesity face, such as joint pain, high cholesterol, diabetes, reflux, apnea and I could go on and on. There isn’t any other treatment for obesity that works as well.